On September 26, 2024, Assistant Lecturer Ms. Zhikal O. Khudhur from the Biology Education Department at Tishk International University (TIU) delivered an insightful seminar on a crucial medical topic: “The Role of Serum Endothelin-1 in Diagnosing and Predicting Outcomes in Patients with Acute Coronary Syndrome Prior to Percutaneous Coronary Intervention (PCI).”
Overview of the Study
Ms. Khudhur’s research examined the potential of serum endothelin-1 (ET-1) as a valuable biomarker for both diagnosing Acute Coronary Syndrome (ACS) and predicting patient outcomes before they undergo PCI. The study compared 90 ACS patients with 104 healthy individuals, evaluating the diagnostic accuracy of ET-1 alongside other established markers like nitric oxide (NO) and neutrophil-to-lymphocyte ratio (NLR).
Key Findings
The presentation highlighted several significant discoveries:
- Superior Diagnostic Accuracy: Serum ET-1 levels were significantly higher in ACS patients. The marker demonstrated the highest diagnostic accuracy (AUC = 0.947), outperforming both NO and NLR.
- Correlation with Myocardial Injury: ET-1 showed strong correlations with cardiac markers CK-MB and Troponin I, which are key indicators of myocardial injury.
- Independent Predictive Value: Through multivariate analysis, the study confirmed that ET-1, along with markers for oxidative stress and inflammation, can independently predict cardiac marker levels.
Conclusion and Future Recommendations
In conclusion, Ms. Khudhur’s study suggests that ET-1 is a highly valuable, non-invasive biomarker for diagnosing ACS and predicting outcomes before PCI. The research recommends that a multi-marker strategy—incorporating endothelial dysfunction, inflammation, and oxidative stress—could further enhance the accuracy of risk assessment in ACS patients. Further studies are recommended to validate these findings in broader populations.
Keywords: Higher Education, Education, Learning, Teaching, University, Medicine, Biology.
