On September 26, 2024, the Biology Education Department at Tishk International University (TIU) hosted a significant internal seminar. The head of the department, Mr. Harmand A. Hama, delivered an insightful presentation on “Micro-RNA Expression Alterations in Colorectal Cancer Prognosis: A Systematic Review.”
Key Insights from the Seminar
Mr. Hama’s presentation shed light on the critical global health issue of Colorectal Cancer (CRC), which is the third most common diagnosed cancer and the second leading cause of cancer-related deaths worldwide. The study specifically focused on the dysregulation of microRNA (miRNA) expression, which has been consistently observed in CRC cases.
The systematic review highlighted several key findings:
- Overexpressed miRNAs: The study found a correlation between the overexpression of seven specific miRNAs (miR-21, miR-211, miR-89, miR-320e, miR-203, miR-200c, and miR-107) and the prognosis of CRC.
- Downregulated miRNAs: Conversely, the downregulation of 14 miRNAs (miR-23b, miR-217, miR-625, miR-124, miR-15a, miR-16, miR-126, miR-34a, miR-7, miR-100, miR-497, miR-215, miR-192, and miR-152) was also associated with CRC prognosis.
- Tumorigenesis and Metastasis: Furthermore, the dysregulation of these miRNAs was also linked to CRC tumorigenesis, progression, and metastasis.
Conclusion and Future Outlook
In conclusion, Mr. Hama emphasized that the dysregulation of OncomirRs (oncogenic miRNAs) and tumor suppressor miRNAs presents a vital area for research, as it can serve as a potent prognostic tool in CRC. However, he stressed the importance of continued research to fully unlock the potential of miRNAs as prognostic biomarkers, which could lead to more effective and personalized management strategies for colorectal cancer patients.
Keywords: Cancer, Cancer Therapy, Medical Education, Higher Education, Biology, Research, Innovation.
